As society ages, the number of patients with heart failure is rapidly increasing. Excessive growth of fibrotic tissue in the heart, known as fibrosis, is associated with the progression of heart failure. A group from the Nagoya University Graduate School of Medicine in Japan has found an enzyme protein kinase N (PKN) that regulates heart fibrosis. The enzyme catalyzes the conversion of heart fibroblasts to myofibroblasts, which threatens the integrity of the heart.
Researchers discover new target for treating heart failure: Protein kinase N
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