Click chemistry PET imaging tracks antisense drug distribution in the brain

Assessing the distribution of a medication in the brain is critical for the treatment of a vast range of neurological disorders, especially conditions such as Parkinson’s and Alzheimer’s diseases. To that end, scientists in the United States and Sweden are developing a method to image therapeutic antisense oligonucleotides in the brain by relying on “click chemistry,” a Nobel Prize-winning technique in which molecules are linked—clicked together—like molecular Lego blocks.

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