3D structure of human clusterin sheds light on Alzheimer’s risk factor

Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia, with symptoms appearing after age 65. Since carriers of clusterin risk alleles have an increased likelihood of developing LOAD, the associated clusterin protein is of interest to researchers. In order to better understand the function of the associated protein, researchers at the Max Planck Institute of Biochemistry have deciphered the molecular basis for the chaperone function of clusterin.

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