Researchers at Academia Sinica have developed the first population-specific polygenic risk score (PRS) models for people of Han Chinese ancestry, achieving unprecedented accuracy in predicting risks for common diseases such as diabetes, heart disease, autoimmune disorders. The study, published in Nature on October 15, 2025, analyzed genomic and health data from more than half a million Taiwanese participants of the Taiwan Precision Medicine Initiative (TPMI) and demonstrates the transformative potential of ancestry-specific genetics in improving precision medicine across East Asia.
Population-specific genetic risk scores advance precision medicine for Han Chinese populations
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